منابع مشابه
Does recycling in germinal centres exist?
A general criterion is formulated to decide if the recycling of B cells exists in germinal centre (GC) reactions. The criterion is independent of the selection and affinity maturation process and based solely on total centroblast population arguments. An experimental test is proposed to verify whether the criterion is fulfilled.
متن کاملF18 fluorodeoxyglucose uptake in progressive transformation of germinal centres
FDG-PET/CT is a widely established imaging modality for staging, restaging and monitoring therapy response in lymphoma patients. Progressive transformation of germinal centres (PTGC) is a benign condition presenting characteristically as asymptomatic lymphadenopathy. This paper presents a case of a 53-year-old man with a history of Hodgkin's disease (HD) whose F(18) FDG-PET/CT scan showed high ...
متن کاملAn analysis of B cell selection mechanisms in germinal centres
Affinity maturation of antibodies during immune responses is achieved by multiple rounds of somatic hypermutation and subsequent preferential selection of those B cells that express B cell receptors with improved binding characteristics for the antigen. The mechanism underlying B cell selection has not yet been defined. By employing an agent-based model, we show that for physiologically reasona...
متن کاملMolecular analysis of IgD-positive human germinal centres.
It is controversially discussed whether human IgM(+)IgD(+)CD27(+) B cells, which carry somatically mutated Ig variable region (IgV) genes, are derived from germinal centres (GC) B cells or originate from another developmental pathway. GC composed of IgM(+)IgD(+) B cells, which co-express the CD70 surface marker, have been described in approximately 10% of tonsils. As IgM(+)IgD(+)CD27(+) B cells...
متن کاملBacterial genomic reorganization upon DNA replication.
Reorganization upon DNA Replication Myllykallio et al. (1) narrowed the replication origin of the archaeon Pyrococcus abyssi down to an 80-kb region (bar on left axis of Fig. 1A), an observation consistent with our prediction (2) of the replication origin of a closely related species, Pyrococcus OT3 (triangle on upper axis of Fig. 1A). Here, we report that a comparison of the genomic sequences ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Reviews Immunology
سال: 2016
ISSN: 1474-1733,1474-1741
DOI: 10.1038/nri.2016.108